IGHE and central nervous system cancer: Indeed, a nested case-control study combining data from four prospective cohort studies have found a statistically significant inverse association between “borderline-elevated” total IgE levels (25–100 kU/L) and glioma (with 169 cases) (OR = 0.63, 95% CI, 0.42–0.93), even though no association was detected between high IgE (>100 kU/L) and glioma (OR = 0.98, 95% CI, 0.61–1.56) [30].