Palugulla et al. confirmed that the presence of polymorphisms in genes SCN4A (rs2302237), SCN9A (rs6746030) and SCN10A (rs12632942) predicts either the development or the severity of chronic OIPN in cancer patients, while patients with mutations in the SCN9A rs6754031 variant allele have a lower risk of severe chronic peripheral neuropathy development. This evidence concerns the gene SCN10A and peripheral neuropathy.