Confocal images of DS MTC brain sections showed many mature SPs with well-defined structures of amyloid protein positive depositions (stained with Aβ42, antibody) but which did not co-localize with p-Tau (stained with AT8, antibody Ser202/Thr 205 epitope; see Fig. 2a-e). The gene discussed is MAPT; the disease is medullary thyroid gland carcinoma.