TREM2 and Dravet syndrome: Similarly, in controls, both the TREM2 and ApoE protein were visible in CPE cells and in stromal macrophages that appeared normal and healthy in structure (Fig. 5e), whereas in DS brains, ApoE was visible in the “Amyloid Biondi” bodies (complex filamentous ring-like structures associated with lipid droplets) and lipofuscin (yellow or brown intracellular structures composed of lipid molecules (Fig. 5f).