There was a correlation between TREM2-T, HLA-DR-A, Tau-H1, and ApoE-ɛ4 (T-A-H1-ɛ4) and a high-risk of dementia in contrast to TREM2-C, HLA-DR-G, Tau-H2, and ApoE-ɛ2 haplotype, which was protective (C-G-H2-ɛ2). The gene discussed is APOE; the disease is dementia.