GSS and acute myeloid leukemia: For example, CD34+ AML cells showed significantly up-regulated expression of GCLC (1.5 fold, p = 0.049), GSS (1.6 fold, p = 0.013), GPX1 (2.5 fold, p = 0.012), and TrxR1 (2.6 fold, p = 0.010) mRNA, consistent with the differences we observed in our western blot analyses.