TXNRD1 and cancer: Increasing numbers of TrxR1 inhibitors including metal-containing molecules (i.e. Auranofin, Cisplatin), selenium-containing molecules (i.e.1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)] ethane), and natural derived chemicals (i.e. Parthenolide, Manumycin A, Curcumin, Juglone, and Piperlongumine) [28,29,44,45] have been reported as leads for the anti-cancer treatment in past few years.