Hence, we examined mGluR1 availability across the brain in living patients with AD, using N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl] -4-11C-methoxy-N-methylbenzamide (11C-ITMM) and PET. This evidence concerns the gene GRM1 and Alzheimer disease.