On the other hand, NQO1 regulation may involve other transcriptional factors and its low expression in a subset of endometrial carcinomas might be related to biological processes independent of NRF2: an extensive chromatin and transcriptomic analysis of these tumors would be required to determine whether NRF2 transcriptional program is indeed skewed in TP53 mutated serous tumors. This evidence concerns the gene NFE2L2 and endometrial carcinoma.