NFE2L2 and neoplasm: No tumor pathological nor clinical features was significantly associated with this high NRF2 nuclear staining (Table 1) although we observed a trend towards a higher proportion of NRF2-high tumors in the TP53/CNH-like tumors (36.4% versus 19.4% in non-TP53/CNH-like tumors, p = 0.052).