Both HOMA-Adiponectin (AUC: 0.712; 95% confidence interval [95CI%]: 0.576–0.825; P = 0.02) and HOMA-IR (AUC: 0.859; 95CI%: 0.740–0.937; P < 0.0001) presented good discriminatory power for the detection of insulin resistance. The gene discussed is ADIPOQ; the disease is Insulin resistance.