RUNX3 and cancer: In the analysis of DNA methylation patterns between the experimental and control groups, some genes related to the progression and development of cancer (p-value<0.05) were hypermethylated in dogs with lymphoma compared with the healthy group: RUNX3 is a tumor suppressor gene, member of the RUNT transcription factor family, in human gastric cancer, it is often inactivated by loss of alleles or by gene silencing secondary to promoter region hypermethylation [71]; RASGRF2 is a tumor suppressor gene that plays a key role in lymphocyte proliferation, T cell signaling, and lymphomagenesis [72].