Indeed, the detection of soluble MICA and MICB in the serum of patients with advanced hepatocellular carcinoma [18] and oral squamous cell carcinoma [19] respectively represents a marker of poorer prognosis, while increased soluble MICA and decreased NKG2D levels are poor prognostic markers in pancreatic cancer [20]. This evidence concerns the gene MICA and oral cavity squamous cell carcinoma.