Abnormal expression of MLCK has been observed in respiratory diseases, pancreatitis, cardiovascular diseases, cancers and inflammatory bowel diseases.17 Cheng et al indicated that ML‐7, a MLCK inhibitor, may inhibit the AS rabbit's plaque formation by improving vascular endothelial dysfunction.34 In line with previous reports, we observed that ML‐7 significantly inhibited LDL level and aortic lipid deposition lesions of mice. Here, MYLK is linked to respiratory system disorder.