It was exhibited that overexpressed XIST and under‐expressed miR‐30a‐5p were more frequently detected in CRC patients characterized by large tumours (4.255, P = 0.039; 5.173, P = 0.023), advanced clinical stage (7.373, P = 0.007; 6.264, P = 0.012) and lymphatic metastasis (5.872, P = 0.015; 4.364, P = 0.037), when compared with under‐expressed XIST and overexpressed miR‐30a‐5p (Table 2). Here, XIST is linked to colorectal carcinoma.