To verify the association between increased SMVs and the lymph node metastasis of OSCC, we then evaluated the correlation of the level of SMVs with the expression level of vascular endothelial growth factor C (VEGF‐C), one of the major pro‐lymphangiogenic growth factors, in the tumour samples of OSCC patients. The gene discussed is VEGFC; the disease is metastatic malignant neoplasm in the lymph nodes.