SH3TC2 and infection: Based on our previously-tested lentiviral vector with demonstrated Schwann cell tropism showing high infection rates in Schwann cells, as well as the rat Mpz promoter, which drives gene expression restricted to myelinating Schwann cells (Sargiannidou et al., 2015; Kagiava et al., 2016), we developed a novel vector to deliver the human SH3TC2 gene into Schwann cells.