SH3TC2 interacts with ERBB2 and plays a role in the regulation of ERBB2 intracellular trafficking from the plasma membrane upon NRG1 activation while dysregulated NRG1/ERBB signalling was found in SH3TC2-deficient Schwann cells that may account for the disturbed axonal size sensing and the hypomyelination present in CMT4C patients (Gouttenoire et al., 2013). Here, SH3TC2 is linked to Charcot-Marie-Tooth disease type 4C.