SH3TC2 interacts with ERBB2 and plays a role in the regulation of ERBB2 intracellular trafficking from the plasma membrane upon NRG1 activation while dysregulated NRG1/ERBB signalling was found in SH3TC2-deficient Schwann cells that may account for the disturbed axonal size sensing and the hypomyelination present in CMT4C patients (Gouttenoire et al., 2013). This evidence concerns the gene ERBB2 and Charcot-Marie-Tooth disease type 4C.