Moreover, CRP has not only beenshown to cause kidney injury, but its circulating levels are also increased in AKIand CKD [66–68].Since oxyradical generation and renal inflammation are both involved in theinitiation and progression of kidney injury, possible pathophysiology mechanisms ofearly renal insults in growth-restricted newborns may include a crosstalk betweenrenal oxidative stress and inflammation. This evidence concerns the gene CRP and chronic kidney disease.