Previous studies demonstrated that inhibition of SALL4 reduced the chemoresistance through induction of cellular apoptosis in lung and colorectal cancer.42, 43, 44 Besides, ChIP assay found that SALL4 directly bound to the promoter of genes that are critically involved in apoptosis in leukemic NB4 cells.6 Also, SALL4 is essential for G1 cell cycle arrest caused by oncoprotein MLL‐AF9 in mixed lineage leukemia rearranged leukemia.45 However, there is no relevant study focusing on the role of SALL4 in radiation‐induced DDR. This evidence concerns the gene KMT2A and colorectal cancer.