confirmed that, following irradiation, impaired autophosphorylation of ATM in Sall4−/− embryonic stem cells (ESCs) are caused by the loss of SALL4.14 Taken together, we hypothesized that SALL4 might regulate radiosensitivity via ATM/Chk2/p53 pathway in NPC. This evidence concerns the gene SALL4 and nasopharyngeal carcinoma.