Dendritic cells dysfunction is one of the major causations of BC, and the increase in the number and activity of mature DCs in tumor tissue by DC vaccine and other approaches can enhance the immune killing effect on tumor.59 Wang et al indicated that B7‐H1 silencing could enhance the antitumor effect of bladder cancer by antigen‐expression DC, which provided a new strategy for BC immunotherapy.60 Aside from BCG and DC vaccines, there are numerous reports on the use of immunotoxin coupled mAb, IFN‐α, IL‐2, etc. in BC immunotherapy.61, 62. Here, IL2 is linked to breast cancer.