Given the recent findings that IL-27p28 exacerbates graft-versus-host disease (GVHD), we hypothesized that targeting the alpha receptor subunit of the IL-27 receptor (IL-27Rα) specifically on T cells would result in a reduction in GVHD severity after allogeneic bone marrow transplantation (allo-BMT). Here, IL27RA is linked to graft versus host disease.