In order to decipher the role of IL-27Rα on T cells, we initially tested the ability of IL-27R deficient T cells to cause GVHD in a MHC-matched but minor histocompatibility antigen (miHA) mismatched murine BMT model, C57BL/6 to BALB.B. This evidence concerns the gene IL27RA and graft versus host disease.