SMIM1 and malaria: The observation by Ndila et al. could mean that (a) SMIM1 is not involved in malaria pathogenesis; (b) the malaria parasite is not a selectable force on the gene; (c) SMIM1 is functionally conserved and thus less polymorphic; (d) the gene is diverse such that the contribution of individual haplotypes were masked in the gene pool.