RBPJ and Hepatic fibrosis: Chu et al. [4] found that C-C motif chemokine receptor 9-positive macrophages activated HSCs and promoted liver fibrosis, Lodder et al. [5] demonstrated that macrophage autophagy protected against liver fibrosis in mice, and He et al. [6] identified that myeloid-specific disruption of recombination signal-binding protein-Jkappa ameliorated hepatic fibrosis by attenuating inflammation.