TGFA and neoplasm: Moreover, compared to tumor tissues treated by TGF-α or SiNPs, the expression of cytokeratin and E-cadherin was increased, and the expression of fibronectin and vimentin was decreased in treatment of TGF-α antibody (Figures 4(d), 4(e), and 4(f)); while being treated with rat IgG, there was no significant change of EMT, proliferation, and apoptosis compared with treated by TGF-α or SiNPs (data not shown).