In a multivariate Cox proportional hazard model, we found 7 predictors including LDH >350U/L, HR>130 times/min, room air PaO2 <70mmHg, later admission to ICU, Anemia (HGB≤90g/L), CD4<50cells/ul, and development of a pneumothorax were associated with poor prognosis in HIV/AIDS patients with PCP. This evidence concerns the gene CD4 and pneumocystosis.