We found that the interaction of CASP10 - CASP1, CASP10- CASP3, CASP10- CASP4, CASP10- CASP9, CASP10- CASP12, CASP8 - CASP3, CASP8 - CASP4, and CASP1 - CASP12 is important for the risk of psoriasis (Table 4). The gene discussed is CASP3; the disease is psoriasis.