Obesity is characterized by a changed physiologic milieu, e.g., alterations in insulin sensitivity, sex hormones, and inflammatory cytokines [2, 3], and consequently, higher BMI has been regarded as risk factor for diseases such as cardiovascular diseases, diabetes, musculoskeletal disorders, and some cancers [4–6]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.