MYC and acute lymphoblastic leukemia: In preclinical studies, OTX015 was observed to possess antiproliferative effects in lymphoma models and affects MYC, NFKB, JAK/STAT pathways, cell cycle regulation and chromatin structure; it increased HEXIM1 mRNA level in AML and ALL cell lines, which is responsible for sequestering the active form of PTEF-b [70].