BRD4 also forms super enhancer complexes with the Mediator complex, a multiprotein transcriptional regulator (containing the CDK8/CDK19/MED12/MED13 kinase module), via which it regulates the expression of oncogenic drivers such as MYC, a super-transcription factor deregulated in a majority of cancers [31]. The gene discussed is MYC; the disease is cancer.