MYC and glioblastoma: reported that JQ1 induced marked G1 cell cycle arrest and apoptosis with significant changes in the expression of important GBM genes; c-MYC, p21CIP1/WAF1, hTERT, Bcl- 2 and BclxL. In vivo, orthotopic GBM tumors showed significant growth repression following treatment with JQ1 [56].