Reduces MYC expressionInduced apoptosis via modulation of the intrinsic apoptotic pathway, tumor regressionSynergistic effect on tumor regression with better tolerance by xenografts than BET inhibitor monotherapyCombination treatment with JQ1 and lapatinib showed stronger growth inhibitory effect of ERRB2-positive breast cancer, reduced levels of ERBB3, IGF1R, DDR1, MET and FGFR. The gene discussed is IGF1R; the disease is breast cancer.