As an example of MYC-independent targeting, genome-wide analysis of JQ1-induced transcriptional response in MYC-driven B-cell lymphoma revealed reduced BRD4 occupancy at the IFNγ PD-L1 ligand Cd274 without affecting MYC occupancy, resulting in a reduction of the CD274 mRNA level. The gene discussed is CD274; the disease is B-cell non-Hodgkin lymphoma.