Medulloblastoma is the most common malignant brain tumor in children and is characterized by amplification of MYC, MYCN and MYCL. JQ1 treatment significantly reduced cell proliferation and induced apoptosis and senescence in different human medulloblastoma cell lines (HD-BM3, ONS-76 and D-341) and effected inhibition of self-renewal and induction of apoptosis in stem cells [53,54]. Here, MYCN is linked to medulloblastoma.