Since the majority of FLs have the t(13–17) and MYC translocation is a common event driving transformation to aggressive lymphoma, a majority of transformed FLs are double-hit lymphomas and are classified as high-grade B-cell lymphoma with MYC and BCL2 or BCL6 translocations or both. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.