The genetic alterations in the three overlapping genes (MAP2K1, PIK3CA and RAF1) revealed by the Damnacanthus indicus C.F.Gaertn prick-related rap1 signal further explored and assessed for the beneficial effects which Damnacanthus indicus C.F.Gaertn may exerts in the treatment of various cancers. This evidence concerns the gene PIK3CA and cancer.