TNF and breast cancer: In module #47, two genes are related to breast cancer have been identified: (1) MAP3K7, also known as TAK1, is a key mediator between survival and cell death in TNF-α-mediated signaling (Totzke et al., 2017); and (2) CCNC, an important transcriptional regulator whose higher expression is associated with shorter relapse-free survival (RFS) and impact the response to adjuvant therapy in breast cancer.