For the leading two features, since the importance of diagnosis age and PR status have been widely examined and recognized in breast cancer (Adami et al., 1986; Boyd et al., 1995; Huang et al., 2000; Bauer et al., 2007) and further confirmed by our results (Figure 2C), we focused on the top five mRNA-seq data co-expression modules ranked from 3 to 7. This evidence concerns the gene PGR and breast cancer.