REN and hypertensive disorder: He et al. found that an Coptis chinensis Franch -constituted formula, Yiqi Huaju formula, lowered blood pressure and serum lipids level through inhibiting mRNA expression of the renal renin, angiotensin II (Ang II), and Ang II receptor, type 1 (AT1R), and inhibited the protein expression of renal AT1R and Ang II receptor type 2 in a high-salt and high-fat diet induced hypertension rat model (He et al., 2015).