Mice which lack the GABAAR δ subunit (Gabrd-/- mice) exhibit depression-like behaviors restricted to the postpartum period and deficits in maternal care (Maguire and Mody, 2008), a finding which has been attributed to the disinhibition of CRH neurons (Sarkar et al., 2011) resulting in elevated corticosterone levels during the peripartum period (Maguire and Mody, 2016). Here, CRH is linked to major depressive disorder.