MELTF and Alzheimer disease: MTf levels have been demonstrated to be increased in the serum of AD subjects compared to healthy controls, and significantly increased in cerebrospinal fluid (CSF) of AD subjects compared to individuals suffering from other CNS diseases (Kennard et al., 1996; Feldman et al., 2001; Kim et al., 2001), highlighting the potential of MTf as a possible AD biomarker.