In addition, we recently showed that although the sputum expression level of IL-1/IL-17 molecular markers most strongly correlated with neutrophilia, all type-2 and type-17 markers, as well as the IL-1 receptor expression levels tended to correlate with each other, indicating a lack of clear-cut separation between these different types of immune responses in asthma [6]. This evidence concerns the gene IL1B and asthma.