The 3 remaining variants have been reported previously as disease causing: CFH c.380G→A, p.(Arg127His)25, 29; CFH c.694C→T, p.(Arg232Ter)30 identified in 2 unrelated families in this cohort; and CFH c.1291T→A, p.(Cys431Ser), which has been identified in the homozygous state underlying membranoproliferative glomerulonephronophthitis type I31 and dense deposit disease.30 The gene discussed is CFH; the disease is dense deposit disease.