Interestingly, in the case of MED12, it was demonstrated experimentally that the substitutions p.Arg961Trp and p.Asn1007Ser (causing FG and Lujan syndromes, respectively), exhibit impaired recruitment of CDK8 onto GLI3-target gene promoters, leading to hyperactivated GLI3-dependent SHH signaling.50 This evidence concerns the gene GLI3 and X-linked intellectual disability with marfanoid habitus.