LAMB3 and Alzheimer disease: The LAMB3 variants reported by Prasad et al. (2016) in AD AI included 2that were also identified in patients with JEB as recurrent variants at hypermutableCpG sites (Kivirikko et al.1996), namely c.1903C>T, p.(R635*), which accounts for 45% to 63% ofall variants identified in LAMB3 in patients with JEB, andc.124C>T, p.(R42*; Kiritsi etal.