To investigate whether the payload into tumor tissue via LyP-1 was still intact, a mixed micelle composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000] (DSPE-PEG2000)-LyP-1 and DSPE-PEG2000-FAM were prepared. This evidence concerns the gene PTPN22 and neoplasm.