In the present study, we investigated the expression of total STAT3 (tSTAT3) and two forms of activated phosphorylated STAT3 (pSTAT3727 and pSTAT3705) in tissue microarrays (TMA) of two cohorts of localized hormone‐naïve PCa patients and analyzed associations between the expression and disease outcome. This evidence concerns the gene STAT3 and posterior cortical atrophy.