Similarly, studies in glioblastoma found that pSTAT3 can have pro‐oncogenic or tumor‐suppressive functions depending the presence of PTEN.35 Therefore more insight into the different STAT3 splice variants and the involvement of other STAT3 cofactors such as ARF, PTEN or SOCS3 may be needed in future studies. This evidence concerns the gene SOCS3 and neoplasm.