Accordingly, in our cohort, cRAGE inversely correlates with the inflammatory marker PAI-1 (Table 2), known to increase in age-associated clinical conditions including cardiovascular diseases, type 2 diabetes (T2DM), obesity and inflammation [50] and shows also an almost significant inverse correlation with CRP (Table 2). Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.