INS and Insulin resistance: Our data expand previous published reports demonstrating that in a healthy population, W/H negatively associates with and is an independent predictor of both RAGE isoforms (Table 2-3, ); interestingly, we also found that esRAGE inversely correlates with insulin, HOMA index and ALT and sRAGE correlations with these insulin resistance-related markers depend exclusively on esRAGE variations (Table 2).