Wnt3A is a well‐known ligand, whose involvement in OA has been previously described in chondrocytes,15, 22, 47 Regarding Wnt7B, its up‐regulation has been described in OA and RA, with consequences in the pathology.43, 48 Wnt3A was no detected neither in SF from HD, nor in those from OA patients. The gene discussed is WNT7B; the disease is rheumatoid arthritis.