AKT1 and cancer: indicate an important role of SP/NK‐1R signaling in cancer progression and metastasis, as well as tumor microenvironment.11, 12 Furthermore, it has been reported that SP/NK‐1R complex potently modulates several signaling cues including Wnt, ERK and Akt in many primary and metastatic human cancer.13, 14, 15 Amongst these signalings, it is imperative to know that Akt has been demonstrated to mediate various pathways of metabolism, proliferation and survival in tumorigenesis, and it is hyperactivated in GBC.16, 17 For instance, Y. Liu et al.