Furthermore, by reproducing experimental results, the simulations support the evidence-based hypothesis that the membrane-bound membrane-type-1 matrix metalloproteinase (MT1-MMP) is the main driver of invasive spread rather than diffusible MDEs such as matrix metalloproteinase-2 (MMP-2), in particular when we switch from diffusion-dominated to haptotaxis-dominated cancer cell invasion. This evidence concerns the gene MMP2 and cancer.