ABCA7 and Alzheimer disease: In Caucasians, three associated SNPs were pinpointed (Table 1, Fig. 1): intronic SNP rs3764650 (odds ratio (OR) = 1.2, Table 1) was the first sentinel SNP in the ABCA7 locus to obtain genome-wide significance [35] and is the most frequently studied variant in ABCA7 regarding the effect of common variants on (endophenotypes of) AD, as described below.