One of the loci with the highest post-GWAS research success rate is the ATP-binding cassette, sub-family A, member 7 (ABCA7) gene, with the identification of both common risk variants with a direct functional consequence on ABCA7, as well as rare coding variants of intermediate to high penetrance providing compelling evidence of the involvement of ABCA7 in AD risk. The gene discussed is ABCA7; the disease is Alzheimer disease.