ABCA7 and Alzheimer disease: Due to the relatively low expression of ABCA7, and consequently low sequencing read counts in RNA-sequencing experiments, it is not trivial to study alternative splicing in ABCA7. Nevertheless, in the largest AD meta-analyzed transcriptome-wide association study (TWAS) to date, significant association was found between ABCA7 splicing—measured in the dorsolateral prefrontal cortex—and AD [108].