Adult congenital heart disease patients had higher use of cardiovascular drugs than referents, with highest use of antithrombotics {27 vs. 6% in referents, OR = 5.83 [95% confidence interval (CI) 5.60–6.07]}, β-blockers [24 vs. 6%, OR = 4.43 (95% CI 4.26–4.61)], and renin–angiotensin–aldosterone system (RAAS) inhibitors [21 vs. 7%, OR = 3.32 (95% CI 3.17–3.47)] (Table 1A). This evidence concerns the gene REN and congenital heart disease.