Similar to PAX3-FOXO1 in rhabdomyosarcoma and EWSR1-associated fusions in Ewing sarcoma28,40,41, our data indicate a substantial co-localization of BRD4 and FUS-DDIT3, and a BET protein-dependent function of FUS-DDIT3 via physical interaction in MLPS. The gene discussed is EWSR1; the disease is rhabdomyosarcoma.