To validate our observations in human samples, we generated a signature specific for SREBP124 (Supplementary Table 4), as a proxy of SREBP1 activation, to interrogate two public datasets of human transcriptional profiles from different physiological and pathological conditions: (i) normal breast tissue with high vs low mammographic density25, a parameter that directly correlates with tissue stiffness26; (ii) lung tissue from patients affected by Idiopathic Pulmonary Fibrosis, a condition linked to pulmonary tissue stiffness27, vs healthy controls28. The gene discussed is SREBF1; the disease is pulmonary fibrosis.