In summary, our study described the overactivation of the Notch1/PDGFRβ/ROCK1 pathway in IPF patient lung tissues, illustrating the facilitating role of the Notch1 pathway in pericyte proliferation and their differentiation toward myofibroblasts, which may further aggravate tissue fibrosis. The gene discussed is PDGFRB; the disease is idiopathic pulmonary fibrosis.