Finally, the authors demonstrate that alleviation of ER stress is sufficient to reduce VSMC loss in the aorta: Indeed, administration of the chemical chaperon tauroursodeoxycholic acid (TUDCA) inhibited pro‐apoptotic gene expression, blunted atherosclerosis progression, and prolonged the lifespan of mice with VSMC‐selective progerin expression (Hamczyk et al, 2019), which most likely die from atherosclerosis‐related causes (Hamczyk et al, 2018). The gene discussed is LMNA; the disease is atherosclerosis.