SFRP1 and gastric cancer: According to the finding of qRT-PCR and Western blot analysis, we found that in contrast with the normal gastric mucosa cell line GES-1, the mRNA and protein expression of SFRP1 was significantly decreased in GC cell lines (BGC-823, AGS, HGC-27, NCI-N87, SGC-7901, MKN45 and MGC-803) (all P < 0.05; Figure 6A,B).