In some case, TNF-α binds to TNFR in the membrane to form Complex by recruiting cellular inhibitor of apoptosis 1/2 (cIAP1/2) to enhance the translocation of NF-κB subunits into the nucleus and promote the transcription of various cytokines and proteins that mediate the progression of cancer or in another aspect, rescue cells from the fatal threats. This evidence concerns the gene BIRC2 and cancer.