We compared expression of α-NRXN3 and β-NRXN3 in mRNAs extracted from the middle frontal cortices of human postmortem brain samples of AD and controls with different “splicing site 5 (SS#5)” NRXN3 haplotypes defined by alleles of the rs8019381 SNP. The gene discussed is NRXN3; the disease is Alzheimer disease.