The presence of systemic infections and increased blood (plasma or serum) concentrations of cytokines including interleukin 1β (IL1β), interleukin 10 (IL10), interleukin 6 (IL6), and tumour necrosis factor α (TNFα) have been associated with sAD and predict cognitive decline [18–22]. The gene discussed is IL1B; the disease is Mental deterioration.